Detecting similar high-dimensional responses to experimental factors between human and model organism (to appear)
AUTHORS:
Suvitaival Tommi
,
Huopaniemi Ilkka,
Ore\vsi\vc Matej,
Kaski Samuel
BOOKTITLE:
NIPS 2011 workshop "From Statistical Genetics to Predictive Models in Personalized Medicine"
PDF:
pdf/suvitaival11nipspm.pdf
@inproceedings{ Suvitaival11nipspm, author = "Suvitaival, Tommi and Huopaniemi, Ilkka and Ore{\v{s}}i{\v{c}}, Matej and Kaski, Samuel", responsibleauthor = "Kaski, Samuel", language = "eng", title = "Detecting similar high-dimensional responses to experimental factors between human and model organism", booktitle = {{NIPS} 2011 workshop "From Statistical Genetics to Predictive Models in Personalized Medicine"}, corerank = "NA", pdf = "suvitaival11nipspm.pdf", note = "Extended abstract", flags = "AIRC HIIT public copy", il = "no", year = "to appear", unitcode = "T3060=99,U9014=1", impactfactor = "D3", abstract = "We present a Bayesian model for analysing the effect of multiple experimental factors in two-species studies without the requirement of a priori known matching. From model studies of human diseases, conducted using *omics technologies and various model organisms, the question emerges: is there something similar in the molecular responses of the different organisms under certain conditions, such as healthy vs. diseased? Our approach provides a generative model for the task of analysing multi-species data, naturally taking into account the additional information about the affecting factors such as gender, age, treatment, or disease status." }